The Researchers Enhancing Alzheimer's Diagnostic (READ), an international multidisciplinary team has developed a new method to facilitate the early diagnosis of Alzheimer's disease and related disorders. The design and validation work leading to this method, called "genetic and genealogical congruence", was carried out by an international multidisciplinary team coordinated by a geriatrician, Dr. Jan-Cédric Hansen*.
The Union des Associations France Alzheimer et maladies apparentées is keen to participate in the publication and dissemination of this seminal work.
This team includes university and hospital researchers from the universities of Rouen and Lille, the Harvard T.H. Chan School of Public Health, the World Humanitarian Forum of the University of Maryland, the College of Population Health of the Prague Center for Global Health, the Führungsstab des Sanitätsdienstes der Bundeswehr, the French Armed Forces health service, clinical geriatricians, managers, and caregivers from public and private health and medico-social establishments, health and
social action inspectors from ARS Normandy, and experts in health policy and economics.
The work offers the possibility of making an early diagnosis of Alzheimer's disease and related disorders thanks to genetic profiles derived from high-throughput sequencing, and by identifying family cases that were previously considered sporadic. In doing so, genetic and genealogical congruence opens up new
diagnostic and therapeutic avenues to provide practitioners with new diagnostic and therapeutic strategies.
Alzheimer's disease and other neuro-evolutionary diseases affect about 10% of people over 75 years of age. They are caused by the interaction of multiple genetic and non-genetic predisposing factors.
- The genetic component is particularly important in this disease,
- The genetic component allows for early diagnosis through a new use of high throughput
sequencing data, accessible to all.
- The genetic component is clearly underestimated in the elderly.
Genetic and genealogical congruence complements this approach by focusing not on a single gene, but on a multiplicity of genes and alleles. This work opens up a new perspective for clinicians to support the early diagnosis of Alzheimer's disease and related disorders based on the presence of at least 20
alleles with a proven statistical link to the disease in question.
Dr Alan James, Professor of History at King's College, UK, highlights in his editorial, that, beyond its scientific aspect, this research enables a new vision on the descent of Louis XIV. Professor Alan James determines a new order of succession of the kings of France integrating a little-known branch of the Bourbons who contributed to the validation of the scientific approach by sharing his genetic and genealogical data.
*Dr Jan-Cédric HANSEN PH Geriatrician Coordinating Doctor at the Centre d'Hébergement et d'Accompagnement Gérontologique (CHAG) in Pacy-sur-Eure (27).
And the multidisciplinary team of Researchers Enhancing Alzheimer's Diagnostic (READ):
- Jean-Marie CARRARA, Professeur, Docteur en Pharmacie, diplômé de Biologie Humaine, spécialiste en Identification et traitement statistique des signaux faibles pour l’aide à la décision, Université de Lille ;
- Don DONAHUE, Chair, Medical and Health Programming Board at World Humanitarian Forum, University of Maryland
- Paul BARACH, Professor, College of Population Health, Thomas Jefferson University
- Momar FAYE, Inspecteur de l'action sanitaire et sociale, ARS Normandie,
- Romain MARTIN, Cadre de Santé, Unité de Médecine Ambulatoire CHU Caen Normandie
- Stefan GÖBBELS, Head for International Cooperation at the Bundeswehr Medical Service
Headquarters
- Elhadji A B DIOUF, Médecin Chef Département Gériatrie. Pôle de Santé Privé du Diaconat Centre
Alsace
- John QUINN, Charles University in Prague Institute of Hygiene and Epidemiology, First Faculty
of Medicine, Prague Center for Global Health
- Thérèse PSIUK, directrice des soins honoraire, experte à l'ANAP (agence nationale pour l'aide à
la performance), membre du comité de pilotage du master II « Coordination des trajectoires de soins »
université de Lille
- Delphine PEYRAT, psychomotricienne en gériatrie, spécialisée dans la prise en soin de
personnes porteuses de maladies neurodégénératives.
- Bachira TOMEH, Chercheur universitaire et conseiller du président de l'Université Rouen
Normandie
- Angèle Flora MENDY, Sociologue, Harvard T.H. Chan School of Public Health
- Jean-Jacques ZAMBROWSKI, médecin interniste, expert en politique et économie de la santé,
président de la Société française de santé digitale., Hôpital Bichat, AP-HP
- Véronique DAREES, Praticien Hospitalier Gériatre, présidente de l'Espace éthique du Centre
Hospitalier Eure-Seine (CHES)
- Hugues LEFORT, Structure des urgences et SMUR, Hôpital d’instruction des armées Laveran,
Marseille, France.
